POF reveals an inclination to possess exons.
Splicing is frequently considered a procedure that happen shortly after transcription. Although not, cotranscriptional splicing try envisioned in the Drosophila over 25 years ago (51). More recent research has showed that cotranscriptional splicing is far more common than just had previously been felt (52) and also have you to splicing can start once the a cotranscriptional event and you may keep posttranscriptionally (6, 50). For this reason, the fresh good exon prejudice stated we have found appropriate for POF joining so you can nascent RNAs. Cotranscriptional splicing is thought in order to believe collaboration ranging from exon detection therefore the rates out of transcription because of the RNP2. Since POF was associated with nascent RNAs, it reduced the speed away from transcription over exons perform define the fresh exon bias observed in the chromatin peak inside the Processor chip-processor chip studies (27).